A mitochondrial-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals key regulators of the mitochondrial one-carbon pool-Reference-Cited by-同舟云学术

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A mitochondrial-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals key regulators of the mitochondrial one-carbon pool

Published:2024 Issue:21 Volume:15 Page:8080-8088
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tenney Logan¹^ORCID,Pham Vanha N.¹^ORCID,Brewer Thomas F.¹^ORCID,Chang Christopher J.¹²³^ORCID

Affiliation:

1. Department of Chemistry, University of California, Berkeley, CA, 94720, USA

2. Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA

3. Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA

Abstract

We report a mitochondrial-targeted activity-based sensor for formaldehyde, MitoRFAP-2, and apply this reagent to probe sources and sinks of the mitochondrial one-carbon pool.

Funder

National Institutes of Health

Canadian Institute for Advanced Research

Directorate for Biological Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC01183J

Reference66 articles.

1. Formaldehyde in China: Production, consumption, exposure levels, and health effects

2. O US EPA , Facts About Formaldehyde , https://www.epa.gov/formaldehyde/facts-about-formaldehyde , (accessed October 18, 2023)

3. A review of human carcinogens—Part F: Chemical agents and related occupations

4. Accumulated hippocampal formaldehyde induces age-dependent memory decline

5. The cellular function and molecular mechanism of formaldehyde in cardiovascular disease and heart development

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