Combining retrosynthesis and mixed-integer optimization for minimizing the chemical inventory needed to realize a WHO essential medicines list-Reference-Cited by-同舟云学术

Combining retrosynthesis and mixed-integer optimization for minimizing the chemical inventory needed to realize a WHO essential medicines list

Published:2020 Issue:2 Volume:5 Page:367-376
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Gao Hanyu¹²³⁴^ORCID,Coley Connor W.¹²³⁴^ORCID,Struble Thomas J.¹²³⁴^ORCID,Li Linyan⁵⁶⁴,Qian Yujie⁷³⁴,Green William H.¹²³⁴^ORCID,Jensen Klavs F.¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Engineering

2. Massachusetts Institute of Technology

3. Cambridge

4. USA

5. Harvard T.H. Chan School of Public Health

6. Boston

7. MIT Computer Science & Artificial Intelligence Laboratory

Abstract

Retrosynthetic pathways suggestions are optimized to minimize the number of unique chemicals required to synthesize multiple products as would be useful for on-demand manufacturing.

Funder

Defense Advanced Research Projects Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RE/C9RE00348G

Reference28 articles.

1. Estimated costs of production and potential prices for the WHO Essential Medicines List

2. Shortages of medicines: a complex global challenge

3. Innovative Approaches to Increase Access to Medicines in Developing Countries