Antibacterial activity of a dual peptide targeting the Escherichia coli sliding clamp and the ribosome

Author:

André Christophe12345ORCID,Veillard Florian678910ORCID,Wolff Philippe2111289ORCID,Lobstein Anne-Marie2111289ORCID,Compain Guillaume12345ORCID,Monsarrat Clément12345ORCID,Reichhart Jean-Marc678910,Noûs Camille131410ORCID,Burnouf Dominique Y.2111289ORCID,Guichard Gilles12345ORCID,Wagner Jérôme E.152161718ORCID

Affiliation:

1. Univ. Bordeaux

2. CNRS

3. Bordeaux INP

4. CBMN

5. UMR 5248

6. Insect Models of Innate Immunity

7. UPR 9022-CNRS

8. Institut de Biologie Moléculaire et Cellulaire

9. 67000 Strasbourg

10. France

11. Architecture et Réactivité de l’ARN

12. UPR 9002

13. Laboratoire Cogitamus

14. 75005 Paris

15. Université de Strasbourg

16. Biotechnologie et Signalisation Cellulaire

17. UMR 7242

18. Ecole Supérieure de Biotechnologie de Strasbourg

Abstract

Bifunctional peptides targeting both the translation and the replication machineries have been developed and shown to act as new antimicrobials.

Funder

Délégation Générale pour l'Armement

Publisher

Royal Society of Chemistry (RSC)

Reference50 articles.

1. Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics, https://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en/ , (accessed April 2020)

2. Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp

3. Structure-Based Design of Short Peptide Ligands Binding onto the E. coli Processivity Ring

4. DNA Sliding Clamps as Therapeutic Targets

5. Pivotal role of the β-clamp in translesion DNA synthesis and mutagenesis in E. coli cells

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3