DFT mechanistic study on the formation of 8-oxoguanine and spiroiminodihydantoin mediated by iron Fenton reactions-Reference-Cited by-同舟云学术

DFT mechanistic study on the formation of 8-oxoguanine and spiroiminodihydantoin mediated by iron Fenton reactions

Published:2021 Issue:28 Volume:50 Page:9842-9850
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Chen Hsing-Yin¹²³⁴^ORCID,Lin Yu-Fen¹²³⁴

Affiliation:

1. Department of Medicinal and Applied Chemistry

2. Kaohsiung Medical University

3. Kaohsiung 80708

4. Taiwan

Abstract

The Fenton oxidation mediated by guanine N7-bound iron(ii) leads to the formation of 8-oxoguanine and spiroiminodihydantoin through multiple reaction pathways involving hydroxyl radical and high-valent iron(iv)-oxo species.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT01508G

Reference55 articles.

1. pH-induced mechanistic changeover from hydroxyl radicals to iron(iv) in the Fenton reaction

2. A computational study of the Fenton reaction in different pH ranges

3. EPR spin-trapping study on the oxidizing species formed in the reaction of the ferrous ion with hydrogen peroxide

4. Importance of Iron Complexation for Fenton-Mediated Hydroxyl Radical Production at Circumneutral pH

5. Why the Reactive Oxygen Species of the Fenton Reaction Switches from Oxoiron(IV) Species to Hydroxyl Radical in Phosphate Buffer Solutions? A Computational Rationale

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