Racemic alkaloids from Macleaya cordata: structural elucidation, chiral resolution, and cytotoxic, antibacterial activities
Author:
Affiliation:
1. Key Laboratory of Structure-Based Drug Design & Discovery
2. Ministry of Education
3. Shenyang Pharmaceutical University
4. Shenyang 110016
5. P. R. China
6. Department of Medicine
7. Mount Sinai School of Medicine
8. New York
9. USA
Abstract
Three pairs of new enantiomeric natural alkaloids (±)-macleayins C-E (1–3), together with five pairs of known racemic alkaloids (4–8), were isolated from the aerial parts of Macleaya cordata.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA05423D
Reference27 articles.
1. In vitro assessment of Macleaya cordata crude extract bioactivity and anticancer properties in normal and cancerous human lung cells
2. Optimization of microwave-assisted extraction of protopine and allocryptopine from stems of Macleaya cordata (Willd) R. Br. using response surface methodology
3. Separation of sanguinarine and chelerythrine in Macleaya cordata (Willd) R. Br. based on methyl acrylate-co-divinylbenzene macroporous adsorbents
4. Structural speculation and identification of alkaloids inMacleaya cordatafruits by high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with a screening procedure
5. Phytochemical and antimicrobial characterization of Macleaya cordata herb
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