A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function-Reference-Cited by-同舟云学术

A glucose-based molecular rotor inhibitor of glycogen phosphorylase as a probe of cellular enzymatic function

Published:2022 Issue:12 Volume:20 Page:2407-2423
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Minadakis Michail-Panagiotis¹^ORCID,Mavreas Konstantinos F.¹^ORCID,Neofytos Dionysios D.²^ORCID,Paschou Maria³,Kogkaki Artemis³,Athanasiou Varvara¹,Mamais Michael¹^ORCID,Veclani Daniele⁴,Iatrou Hermis¹^ORCID,Venturini Alessandro⁴,Chrysina Evangelia D.²^ORCID,Papazafiri Panagiota³^ORCID,Gimisis Thanasis¹^ORCID

Affiliation:

1. Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece

2. Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece

3. Department of Biology, National and Kapodistrian University of Athens, 15771 Athens, Greece

4. Istituto ISOF, Area della Ricerca di Bologna CNR, Via P. Gobetti 101, 40129 Bologna, Italy

Abstract

Synthesis and study of RotA, an inhibitor of glycogen phosphorylase (GP), which when bound at the active site of GP, produces a strong fluorescence signal, allowing utilization of RotA as a probe that brings GP “to light” in the cellular milieu.

Funder

European Regional Development Fund

Center for Neuroscience Research

European Social Fund

H2020 Marie Skłodowska-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB02211C

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1. FLUORESZENZSPEKTRUM UND FRANCK-CONDON-PRINZIP IN LÖSUNGEN AROMATISCHER VERBINDUNGEN

2. Die Viskositätsabhängigkeit der Fluoreszenzquantenausbeuten einiger Farbstoffsysteme

3. Structural effects on the electrochemisty and charge distribution of mono-, di-, and tri-cyanovinyl aromatic compounds

4. Reinterpretation of the anomalous fluorescense of p-n,n-dimethylamino-benzonitrile

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