Lewis acid-catalyzed double addition of indoles to ketones: synthesis of bis(indolyl)methanes with all-carbon quaternary centers-Reference-Cited by-同舟云学术

Lewis acid-catalyzed double addition of indoles to ketones: synthesis of bis(indolyl)methanes with all-carbon quaternary centers

Published:2020 Issue:44 Volume:18 Page:9060-9064
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lee Si On¹²³⁴,Choi Jeongin¹²³⁴,Kook Seunghoon¹²³⁴,Lee Sarah Yunmi¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Yonsei University

3. Seoul 03722

4. South Korea

Abstract

A boron or silicon Lewis acid-catalyzed synthesis of bis(indolyl)methanes with all-carbon quaternary centers, including a tetra-aryl carbon center, by the two-fold addition of indoles to a broad range of ketones has been developed.

Funder

National Research Foundation of Korea

Yonsei University

POSCO TJ Park Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01916J

Reference64 articles.

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4. Synthesis of a new bis(indolyl)methane that inhibits growth and induces apoptosis in human prostate cancer cells

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