The anticancer agent ellipticine binds to glycosaminoglycans at mildly acidic pH characteristic of the extracellular matrix of tumor tissues
Author:
Affiliation:
1. Biomolecular Self-Assembly Group
2. Institute of Materials and Environmental Chemistry
3. Research Centre for Natural Sciences
4. Hungarian Academy of Sciences
5. Budapest
Abstract
This communication demonstrates the pH dependent glycosaminoglycan binding of the anticancer plant alkaloid ellipticine.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA23437A
Reference43 articles.
1. Ellipticines as DNA-Targeted Chemotherapeutics
2. The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs
3. Visualization of drug-nucleic acid interactions at atomic resolution
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