Cancer molecular biology and strategies for the design of cytotoxic gold(i) and gold(iii) complexes: a tutorial review-Reference-Cited by-同舟云学术

Cancer molecular biology and strategies for the design of cytotoxic gold(i) and gold(iii) complexes: a tutorial review

Published:2021 Issue:47 Volume:50 Page:17413-17437
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

van der Westhuizen Danielle¹^ORCID,Bezuidenhout Daniela I.²^ORCID,Munro Orde Q.¹^ORCID

Affiliation:

1. Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Johannesburg 2050, South Africa

2. Laboratory of Inorganic Chemistry, Environmental and Chemical Engineering, University of Oulu, P. O. Box 3000, 90014 Oulu, Finland

Abstract

A perspective on the development of gold(i/iii) anticancer agents is given, covering the core concepts of apoptosis in cancer cell biology and macromolecular drug targets. Design elements that elicit cytotoxicity and stability are highlighted.

Funder

National Research Foundation

University of the Witwatersrand, Johannesburg

Oulun Yliopisto

Department of Science and Technology, Republic of South Africa

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT02783B

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