Design, and synthesis of selectively anticancer 4-cyanophenyl substituted thiazol-2-ylhydrazones-Reference-Cited by-同舟云学术

Design, and synthesis of selectively anticancer 4-cyanophenyl substituted thiazol-2-ylhydrazones

Published:2022 Issue:52 Volume:12 Page:34126-34141
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Mehmood Hasnain¹,Musa Mustapha²,Woodward Simon²^ORCID,Hossan Md Shahadat³,Bradshaw Tracey D.³^ORCID,Haroon Muhammad¹,Nortcliffe Andrew⁴^ORCID,Akhtar Tashfeen¹^ORCID

Affiliation:

1. Department of Chemistry, Mirpur University of Science and Technology (MUST), 10250-Mirpur (AJK), Pakistan

2. GSK Carbon Neutral Laboratories for Sustainable Chemistry, University of Nottingham, Triumph Road Nottingham, NG7 2TU, UK

3. School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

4. School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK

Abstract

Cyclization of substituted thiosemicarbazones with α-bromo-4-cyanoacetophenone allows rapid single-step sustainable syntheses of 4-cyanophenyl-2-hydrazinylthiazoles libraries (30 examples, 66–79%).

Funder

Higher Education Commission, Pakistan

University of Nottingham

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03226K

Reference39 articles.

1. Green Approaches in Medicinal Chemistry for Sustainable Drug Design , ed. B. Banik , Elsevier , Amsterdam , 2020 , p. 1021

2. Pharmaceutical industry riding the wave of sustainability: Review and opportunities for future research