OPENchip: an on-chip in situ molecular profiling platform for gene expression analysis and oncogenic mutation detection in single circulating tumour cells

Author:

Lee Amos C.1234ORCID,Svedlund Jessica56789,Darai Evangelia56789,Lee Yongju10234,Lee Daewon11234,Lee Han-Byoel121331415,Kim Sung-Min1613314,Kim Okju10234,Bae Hyung Jong17181920,Choi Ahyoun1234,Lee Sumin10234,Jeong Yunjin10234,Song Seo Woo10234,Choi Yeongjae212314,Yeom Huiran10234,Lee Caleb S.22232420,Han Wonshik121331415,Lee Dong Soon161331425,Jang Jin-Young121331416,Madaboosi Narayanan56789,Nilsson Mats56789,Kwon Sunghoon123410

Affiliation:

1. Interdisciplinary Program in Bioengineering

2. Seoul National University

3. Seoul

4. South Korea

5. Science for Life Laboratory

6. Department of Biochemistry and Biophysics

7. Stockholm University

8. Stockholm

9. Sweden

10. Department of Electrical and Computer Engineering

11. BK21+ Creative Research Engineer Development for IT

12. Department of Surgery

13. Seoul National University College of Medicine

14. Republic of Korea

15. Biomedical Research Institute

16. Cancer Research Institute

17. Department of Mechanical Science and Engineering

18. University of Illinois at Urbana-Champaign

19. Urbana

20. USA

21. Nano Systems Institute

22. Departments of Bioengineering and Materials Science and Engineering

23. University of California

24. Berkeley

25. Department of Laboratory Medicine

Abstract

On-chip in situ molecular profiling for gene expression analysis and oncogenic mutation detection in single circulating tumour cells is presented.

Funder

Vetenskapsrådet

Cancerfonden

National Research Foundation of Korea

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

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