Recent advances in microfluidics for single-cell functional proteomics

Author:

Gebreyesus Sofani Tafesse123ORCID,Muneer Gul145ORCID,Huang Chih-Cheng1ORCID,Siyal Asad Ali1ORCID,Anand Mihir145,Chen Yu-Ju1346,Tu Hsiung-Lin1246ORCID

Affiliation:

1. Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan

2. Nano Science and Technology Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan

3. Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan

4. Chemical Biology and Molecular Biophysics Program, Taiwan International Graduate Program, Academia Sinica, Taipei 11529, Taiwan

5. Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan

6. Genome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei 10617, Taiwan

Abstract

This article covers exciting developments of recent microfluidics-based single-cell proteomics methods and their utilizations to tackle important biological questions for both basic and translational research.

Funder

Academia Sinica

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference270 articles.

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2. D. J.Perry , in Hemostasis and Thrombosis Protocols , ed. D. J. Perry and K. J. Pasi , Humana Press , Totowa, NJ , 1999 , pp. 31–38

3. Single-cell genome sequencing: current state of the science

4. mRNA-Seq whole-transcriptome analysis of a single cell

5. Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

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