Transformation of the shape and shrinking the size of acid-resistant metal–organic frameworks (MOFs) for use as the vehicle of oral proteins

Author:

Yang Li12,Guo Jun3ORCID,Wang Liwen4,Tang Sicheng5ORCID,Wang Ai-fang6,Zheng Shengwu7,Guo Zhiyong3ORCID,Zan Xingjie85ORCID

Affiliation:

1. Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. College of Materials Science and Engineering, Fuzhou University, Fuzhou 350118, PR China

4. Department of Ophthalmology, Huzhou Central Hospital, Affiliated Central hospital Huzhou University, Huzhou, China

5. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Key Laboratory of Perioperative Medicine, Wenzhou 325001, China

6. Department of Critical Care Medicine, the People's Hospital of Yuhuan, Taizhou, Zhejiang 317600, China

7. Wenzhou Celecare Medical Instruments Co., Ltd, Wenzhou, China

8. School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang Province, 325035, PR China

Abstract

The oral delivery of protein-based drugs is of great significance, but faces various obstacles, including the deactivation of proteins by the low stomach pH, the high concentration of protease and poor transport through intestinal bio-barriers.

Funder

Recruitment Program of Global Experts

Science and Technology Plan Project of Wenzhou, China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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