OligoTRAFTACs: A generalizable method for transcription factor degradation
Author:
Affiliation:
1. Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT, 06511, USA
2. Department of Pharmacology, Yale University, New Haven, CT, 06511, USA
3. Department of Chemistry, Yale University, New Haven, CT, 06511, USA
Abstract
Funder
American Cancer Society
Mark Foundation For Cancer Research
National Cancer Institute
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00138A
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1. Proteasome Function Determines Cellular Homeostasis and the Rate of Aging
2. Illuminating the ubiquitin/proteasome system
3. PROTACs: An Emerging Therapeutic Modality in Precision Medicine
4. Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
5. Targeting the Undruggable Proteome: The Small Molecules of My Dreams
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