NMR study of the interaction of fluorescent 3-hydroxy-4-pyridinone chelators with DMPC liposomes
Author:
Affiliation:
1. REQUIMTE-UCIBIO
2. Departamento de Química e Bioquímica
3. Faculdade de Ciências
4. Universidade do Porto
5. 4169-007 Porto
6. REQUIMTE-LAVQ
7. Instituto de Ciências Biomédicas de Abel Salazar
8. Porto
9. Portugal
Abstract
The NMR results corroborate the fact that the presence of the ethyl substituents in the amino groups of the xanthene ring and the thiourea link are fundamental to the ability of the chelator to diffuse across the lipid bilayer and consequently relevant for their enhanced biological activity.
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2016/CP/C5CP05273D
Reference40 articles.
1. Novel tetradentate chelators derived from 3-hydroxy-4-pyridinone units: synthesis, characterization and aqueous solution properties
2. Investigation of the insulin-like properties of zinc(II) complexes of 3-hydroxy-4-pyridinones: Identification of a compound with glucose lowering effect in STZ-induced type I diabetic animals
3. Distinctive EPR signals provide an understanding of the affinity of bis-(3-hydroxy-4-pyridinonato) copper(ii) complexes for hydrophobic environments
4. Iron speciation by microsequential injection solid phase spectrometry using 3-hydroxy-1(H)-2-methyl-4-pyridinone as chromogenic reagent
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