Direct C–H aminocarbonylation of N-heteroarenes with isocyanides under transition metal-free conditions

Author:

Zhou Zhong1234,Ji Huihui1234,Li Qing1234,Zhang Qian1234,Li Dong12345ORCID

Affiliation:

1. Hubei Provincial Key Laboratory of Green Materials for Light Industry

2. Hubei University of Technology

3. Wuhan 430068

4. China

5. Hubei Key Laboratory of Drug Synthesis and Optimization

Abstract

A C–C bond forming amide synthesis through direct C–H aminocarbonylation of N-heteroarenes with isocyanides was developed. The reaction was mediated by an inorganic persulfate salt under transition metal-free conditions.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference103 articles.

1. J. Zabicky , The Chemistry of Amides , Interscience , London , 1970

2. A. Greenberg , C. M.Breneman and J. F.Liebman , The Amide Linkage: Structural Significance in Chemistry, Biochemistry, and Materials Science , Wiley-Interscience , New York , 2000

3. Chemical Synthesis of Natural Product Peptides:  Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides

4. Analysis of the reactions used for the preparation of drug candidate molecules

5. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

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