Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization?

Author:

Besleaga Iuliana1ORCID,Raptová Renáta23,Stoica Alexandru-Constantin4ORCID,Milunovic Miljan N. M.1ORCID,Zalibera Michal2ORCID,Bai Ruoli5,Igaz Nóra6,Reynisson Jóhannes7ORCID,Kiricsi Mónika7,Enyedy Éva A.89ORCID,Rapta Peter2,Hamel Ernest5ORCID,Arion Vladimir B.14ORCID

Affiliation:

1. Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Straße 42, A-1090 Vienna, Austria

2. Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, SK-81237 Bratislava, Slovakia

3. Institute of Physical and Theoretical Chemistry, Graz University of Technology, Stremayrgasse 9/II, A-8010 Graz, Austria

4. Inorganic Polymers Department, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Gr. Ghica Voda 41 A, Iasi 700487, Romania

5. Molecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, USA

6. Department of Biochemistry and Molecular Biology, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary

7. School of Pharmacy and Bioengineering, Keele University, Newcastle-under-Lyme, Staffordshire ST5 5BG, UK

8. Department of Molecular and Analytical Chemistry, Interdisciplinary Excellence Centre, University of Szeged, Dóm tér 7-8, H-6720 Szeged, Hungary

9. MTA-SZTE Lendület Functional Metal Complexes Research Group, University of Szeged, Dóm tér 7, H-6720 Szeged, Hungary

Abstract

The metal-to-ligand stoichiometry and metal identity are of primary importance for the development of metal complexes of thiosemicarbazones as effective inhibitors of tubulin polymerization.

Funder

Austrian Science Fund

Agentúra na Podporu Výskumu a Vývoja

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

European Cooperation in Science and Technology

Magyar Tudományos Akadémia

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

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