Utility of dansyl chloride for the establishment of a sensitive spectrofluorimetric approach for estimating midodrine hydrochloride: application to content uniformity testing

Author:

Derayea Sayed M.1ORCID,Abdelgaleel Mahmoud2ORCID,Nagi Dalia M.1,Oraby Mohamed3,Khashaba Pakinaz Y.45

Affiliation:

1. Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Deraya University, New Mina City, Minia, Egypt

3. Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt

4. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sphinx University, New Assiut City, Assiut, Egypt

5. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Abstract

Midodrine interacts with dansyl chloride to yield a highly fluorescent product with a large Stokes shift. The reaction provided a highly sensitive spectrofluorimetric method for determining midodrine as well as testing content uniformity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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