Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I-Reference-Cited by-同舟云学术

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Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I

Published:2006 Issue:9 Volume:4 Page:1768
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Peng Hairuo,Carrico Dora,Thai Van,Blaskovich Michelle,Bucher Cynthia,Pusateri Erin E.,Sebti Said M.,Hamilton Andrew D.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2006/OB/B517572K

Reference32 articles.

1. Structure and biological effects of lipid modifications on proteins

2. PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

3. Structure of mammalian protein geranylgeranyltransferase type-I

4. Direct Demonstration of Geranylgeranylation and Farnesylation of Ki-Ras in Vivo

5. K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

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