Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazin spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition-Reference-Cited by-同舟云学术

Asymmetric synthesis of chiral 1,2-oxazinane and hexahydropyridazin spirocyclic scaffolds by organocatalytic [4 + 2] cycloaddition

Published:2022 Issue:25 Volume:12 Page:15713-15717
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tian Heng-Zhi¹,Tang Qing-Gang¹,Lin Guo-Qiang¹²,Sun Xing-Wen¹²^ORCID

Affiliation:

1. Department of Chemistry, Fudan University, Shanghai 200433, China

2. Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Abstract

Chiral 1,2-oxazinane spiro-oxindole and chiral hexahydropyridazin spiro-oxindole skeletons are made through asymmetric organocatalytic reactions. Corresponding products were produced in good to excellent yield, excellent diastereoselectivity and good enantioselectivity.

Funder

Natural Science Foundation of Shanghai

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA02759C

Reference32 articles.

1. Detection of VM55599 and Preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: Biosynthetic Implications

2. Microbiological Hydroxylation at Eight Individual Carbon Atoms of Marcfortine A

3. Total synthesis and isolation of citrinalin and cyclopiamine congeners

4. Enantioselective Total Syntheses of Citrinadins A and B. Stereochemical Revision of Their Assigned Structures

5. Enantioselective Total Synthesis of (−)-Citrinadin A and Revision of Its Stereochemical Structure

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