Turn up the cellular power generator with vitamin E analogue formulation
Author:
Affiliation:
1. NanoTherapeutics Research Laboratory
2. Department of Chemistry
3. University of Georgia
4. Athens
5. USA
Abstract
We report cancer cell selective activation of mitochondrial ATP synthase using a suitably designed chemical formulation of alpha-tocopheryl succinate.
Funder
Georgia Research Alliance
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00481D
Reference38 articles.
1. Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
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3. Down-regulation of Mitochondrial F1F0-ATP Synthase in Human Colon Cancer Cells with Induced 5-Fluorouracil Resistance
4. Up-regulation of the ATPase Inhibitory Factor 1 (IF1) of the Mitochondrial H+-ATP Synthase in Human Tumors Mediates the Metabolic Shift of Cancer Cells to a Warburg Phenotype
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