Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation-Reference-Cited by-同舟云学术

Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation

Published:2023 Issue:15 Volume:14 Page:7247-7269
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Sun Wei¹,Wang Qingpeng¹^ORCID,Zhang Ruiyan¹,Zhang Ning¹^ORCID

Affiliation:

1. Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, Shandong 252000, China

Abstract

In EAE, KD inhibits demyelination, neuroinflammation and chemokines/chemokine receptors, and promotes M1 to M2 switching in microglia, as demonstrated by the TLR4/NF-κB/HDAC3/P2X7R/NLRP3 pathway and the JAK1/STAT1 pathway.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Liaocheng University

Youth Innovation Technology Project of Higher School in Shandong Province

Taishan Scholar Foundation of Shandong Province

Open Project of Shandong Collaborative Innovation Center for Antibody Drugs

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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