Development of functionalized hollow microporous organic capsules encapsulating morphine – an in vitro and in vivo study

Author:

Razzaque Shumaila12345,Cai Chen67859,Lu Qun-Wei67859,Huang Feng-Zhen1011121314,Li Yu-Sang1011121314,Tang He-Bin1011121314,Hussain Irshad1516171819,Tan Bien12345

Affiliation:

1. Key Laboratory for Large-Format Battery Materials and System

2. Ministry of Education

3. Hubei Key Laboratory of Material Chemistry and Service Failure

4. School of Chemistry and Chemical Engineering

5. Huazhong University of Science and Technology

6. Key Laboratory of Molecular Biophysics of Ministry of Education

7. College of Life Science and Technology

8. Center for Human Genome Research

9. Wuhan

10. Department of Pharmacology

11. School of Pharmaceutical Sciences

12. South-Central University for Nationalities

13. Wuhan 430074

14. China

15. Department of Chemistry

16. SBA School of Science & Engineering (SSE)

17. Lahore University of Management Sciences (LUMS)

18. DHA

19. Lahore Cantt-54792

Abstract

Carboxylic group functionalized hollow microporous organic capsules (HMOCs) are synthesized that show extraordinary high encapsulation efficiency of morphine·HCl and its promising prolonged release.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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