Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds-Reference-Cited by-同舟云学术

Construction of sulfur-containing compounds with anti-cancer stem cell activity using thioacrolein derived from garlic based on nature-inspired scaffolds

Published:2022 Issue:1 Volume:20 Page:196-207
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yoneda Taichi¹,Kojima Naoto¹,Matsumoto Takahiro¹^ORCID,Imahori Daisuke¹^ORCID,Ohta Tomoe²^ORCID,Yoshida Tatsusada²^ORCID,Watanabe Tetsushi¹,Matsuda Hisashi¹,Nakamura Seikou¹^ORCID

Affiliation:

1. Kyoto Pharmaceutical University, 1 Misasagi-Shichono-cho, Yamashina-ku, Kyoto 607-8412, Japan

2. Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch-Cho, Sasebo, Nagasaki 859-3298, Japan

Abstract

We reported for the first time that thioacroleinproduced by allicin, a major component in garlic, undergoes the regioselective sequential double Diels–Alder reaction.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB01992A

Reference42 articles.

1. The chemistry of alkyl thiosulfate esters. 8. (E,Z)-Ajoene: a potent antithrombotic agent from garlic

2. Systemic Approaches Identify a Garlic-Derived Chemical, Z-ajoene, as a Glioblastoma Multiforme Cancer Stem Cell-Specific Targeting Agent

3. Characterization of E- and Z-ajoene obtained from different varieties of garlics

4. Application of the DataChip/MetaChip technology for the evaluation of ajoene toxicity in vitro

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