Intermolecular CDC amination of remote and proximal unactivated Csp3–H bonds through intrinsic substrate reactivity – expanding towards a traceless directing group-Reference-Cited by-同舟云学术

Intermolecular CDC amination of remote and proximal unactivated Csp3–H bonds through intrinsic substrate reactivity – expanding towards a traceless directing group

Published:2021 Issue:46 Volume:12 Page:15318-15328
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Rajamanickam Suresh¹^ORCID,Saraswat Mayank²^ORCID,Venkataramani Sugumar²^ORCID,Patel Bhisma K.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Guwahati, North Guwahati Address, Assam-781039, India

2. Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, Knowledge City, Manauli, SAS Nagar, 140306, India

Abstract

An intermolecular amination at the distal methylene carbon has been realized in an appended alkyl chain with electron withdrawing groups. Traceless remote Csp3–H functionalization has been accomplished using borate esters.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04365J

Reference86 articles.

1. Chemical mechanisms of catalysis by cytochromes P-450: a unified view