Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels-Reference-Cited by-同舟云学术

Understanding substrate binding and the role of gatekeeping residues in PigC access tunnels

Published:2021 Issue:21 Volume:57 Page:2681-2684
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Brands Stefanie¹²³⁴⁵^ORCID,Sikkens Jarno G.¹²³⁴⁵,Davari Mehdi D.¹²³⁴⁵^ORCID,Brass Hannah U. C.⁶⁷⁸³⁹^ORCID,Klein Andreas S.⁶⁷⁸³⁹^ORCID,Pietruszka Jörg⁶⁷⁸³⁹^ORCID,Ruff Anna Joëlle¹²³⁴⁵^ORCID,Schwaneberg Ulrich¹²³⁴⁵^ORCID

Affiliation:

1. Lehrstuhl für Biotechnologie

2. RWTH Aachen University

3. Bioeconomy Science Center (BioSC)

4. Worringerweg 3

5. Aachen 52074

6. Institute of Bioorganic Chemistry

7. Heinrich Heine University Düsseldorf located at Forschungszentrum Jülich

8. Stetternicher Forst

9. Building 15.8

Abstract

Prodigiosin ligase PigC has been engineered by semi-rational design to accept short chain-pyrroles, providing molecular understanding of access tunnels and the substrate-binding pocket.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC08226K

Reference30 articles.

1. The biosynthesis and regulation of bacterial prodiginines

2. Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products

3. New Prodigiosin Derivatives Obtained by Mutasynthesis in Pseudomonas putida

4. Prodigiosin and its potential applications

5. Insights into the anti-infective properties of prodiginines

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