Synthetic studies toward the brasilinolides: controlled assembly of a protected C1–C38 polyol based on fragment union by complex aldol reactions-Reference-Cited by-同舟云学术

Synthetic studies toward the brasilinolides: controlled assembly of a protected C1–C38 polyol based on fragment union by complex aldol reactions

Published:2015 Issue:20 Volume:13 Page:5716-5733
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Paterson Ian¹²³,Housden Michael P.¹²³,Cordier Christopher J.¹²³,Burton Paul M.¹²³,Mühlthau Friedrich A.¹²³,Loiseleur Olivier⁴⁵⁶

Affiliation:

1. University Chemical Laboratory

2. Cambridge

3. UK

4. Syngenta Crop Protection AG

5. 4332 Stein

6. Switzerland

Abstract

A modular strategy for the synthesis of the immunosuppressant macrolide brasilinolide A was adopted based on coupling suitable northern and southern fragments.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB00498E

Reference85 articles.

1. The Biosynthetic Logic of Polyketide Diversity

2. The exploration of macrocycles for drug discovery — an underexploited structural class

3. Advances in the Total Synthesis of Biologically Important Marine Macrolides

4. Actin-Binding Marine Macrolides: Total Synthesis and Biological Importance

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