Semi-enzymatic acceleration of oxidative protein folding by <i>N</i>-methylated heteroaromatic thiols-Reference-Cited by-同舟云学术

Semi-enzymatic acceleration of oxidative protein folding by N-methylated heteroaromatic thiols

Published:2023 Issue:28 Volume:14 Page:7630-7636
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Okada Shunsuke¹,Matsumoto Yosuke¹,Takahashi Rikana²,Arai Kenta²³^ORCID,Kanemura Shingo⁴,Okumura Masaki⁵^ORCID,Muraoka Takahiro¹⁶⁷^ORCID

Affiliation:

1. Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan

2. Department of Chemistry, School of Science, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan

3. Institute of Advanced Biosciences, Tokai University, Kitakaname, Hiratsuka-shi, Kanagawa, 259-1292, Japan

4. School of Science, Kwansei Gakuin University, 1 Gakuen Uegahara, Sanda, Hyogo 669-1330, Japan

5. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 6-3 Aramaki-Aza-Aoba, Aoba-ku, Sendai 980-8578, Japan

6. Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3-8-1 Harumi-cho, Fuchu, Tokyo 183-8538, Japan

7. Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakato, Takatsu-ku, Kawasaki, Kanagawa 213-0012, Japan

Abstract

We report the first example of a synthetic thiol-based compound that promotes oxidative protein folding upon 1-equivalent loading to the disulfide bonds in the client protein to afford the native form in over 70% yield.

Funder

Japan Society for the Promotion of Science

Asahi Glass Foundation

Takeda Science Foundation

Kanagawa Institute of Industrial Science and Technology

Japan Science and Technology Corporation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01540H