Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability-Reference-Cited by-同舟云学术

Discovery of carboxyl-containing heteroaryldihydropyrimidine derivatives as novel HBV capsid assembly modulators with significantly improved metabolic stability

Published:2023 Issue:11 Volume:14 Page:2380-2400
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Zhao Shujie¹^ORCID,Wang Ya²,Zhang Xujie¹^ORCID,Qiao Lijun²,Wang Shuo¹,Jin Yu¹,Wu Shuo²,Li Yuhuan²,Zhan Peng¹,Liu Xinyong¹^ORCID

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, PR China

2. CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050 Beijing, PR China

Abstract

Novel HBV capsid assembly modulators, 6a-25 and 6b-9, showed significantly improved metabolic stability compared to the lead compound GLS4.

Funder

National Natural Science Foundation of China

Chinese Academy of Medical Sciences Initiative for Innovative Medicine

Key Technology Research and Development Program of Shandong Province

Taishan Scholar Project of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00461A

Reference47 articles.

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2. The host–pathogen interaction during HBV infection: immunological controversies

3. Viral Hepatitis B: Clinical and Epidemiological Characteristics

4. WHO , HBV fact sheet, 2020.07.27: Available from: https://www.who.int/zh/news-room/fact-sheets/detail/hepatitis-b

5. Hepatitis B virus infection

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