The first radiosynthesis of 2-amino-5-[18F]fluoropyridines via a “minimalist” radiofluorination/palladium-catalyzed amination sequence from anisyl(2-bromopyridinyl)iodonium triflate-Reference-Cited by-同舟云学术

The first radiosynthesis of 2-amino-5-[18F]fluoropyridines via a “minimalist” radiofluorination/palladium-catalyzed amination sequence from anisyl(2-bromopyridinyl)iodonium triflate

Published:2019 Issue:26 Volume:17 Page:6359-6363
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Pauton Mathilde¹²³⁴⁵,Gillet Raphaël¹²³⁴⁵,Aubert Catherine⁶⁷⁸⁹¹⁰,Bluet Guillaume⁶⁷⁸⁹¹⁰,Gruss-Leleu Florence⁶⁷⁸⁹¹⁰,Roy Sébastien⁶⁷⁸⁹¹⁰,Perrio Cécile¹²³⁴⁵^ORCID

Affiliation:

1. Normandie Univ

2. UNICAEN

3. CEA

4. CNRS

5. ISTCT-UMR 6030

6. Sanofi R&D

7. IDD

8. Isotope Chemistry

9. 94403 Vitry sur Seine Cedex

10. France

Abstract

Radiofluorination of anisyl(2-bromopyridinyl)iodonium triflate under “minimalist” conditions: an entry to 2-amino-5-[¹⁸F]fluoropyridines via Buchwald–Hartwig amination.

Funder

Association Nationale de la Recherche et de la Technologie

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01187K

Reference44 articles.

1. Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation

2. Design, synthesis and structure–activity relationship of novel tricyclic benzimidazolone derivatives as potent 18kDa translocator protein (TSPO) ligands