Mycobacterium tuberculosis histidinol dehydrogenase: biochemical characterization and inhibition studies-Reference-Cited by-同舟云学术

Mycobacterium tuberculosis histidinol dehydrogenase: biochemical characterization and inhibition studies

Published:2016 Issue:34 Volume:6 Page:28406-28418
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Lunardi Juleane¹²³⁴⁵,Borges Martinelli Leonardo Kras¹²³⁴⁵,Raupp Alessandra Silva¹²³⁴⁵,Sacconi Nunes José Eduardo⁶⁴⁵,Rostirolla Diana Carolina¹²³⁴⁵,Saraiva Macedo Timmers Luís Fernando⁷⁸³⁴⁵,Villela Anne Drumond¹²³⁴⁵,Pissinate Kenia¹²³⁴⁵,Limberger Jones¹²³⁴⁵,Norberto de Souza Osmar¹²³⁴⁵^ORCID,Basso Luiz Augusto¹²³⁴⁵,Santos Diógenes Santiago¹²³⁴⁵,Machado Pablo¹²³⁴⁵

Affiliation:

1. Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)

2. Centro de Pesquisas em Biologia Molecular e Funcional

3. Pontifícia Universidade Católica do Rio Grande do Sul

4. Porto Alegre

5. Brazil

6. Quatro G Pesquisa & Desenvolvimento Ltda.

7. Laboratório de Bioinformática

8. Modelagem e Simulação de Biossistemas (LABIO)

Abstract

We describe a series of biochemical studies on recombinantMycobacterium tuberculosisHisD (MtHisD) and the synthesis of a series of compounds which are, to the best of our knowledge, the first inhibitors ofMtHisD activity reported in the literature.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA03020C

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