Tethering of rhBMP-2 upon calcium phosphate cement via alendronate/heparin for localized, sustained and enhanced osteoactivity-Reference-Cited by-同舟云学术

Tethering of rhBMP-2 upon calcium phosphate cement via alendronate/heparin for localized, sustained and enhanced osteoactivity

Published:2017 Issue:33 Volume:7 Page:20281-20292
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhu Jiaoyang¹²³⁴⁵,Huang Baolin¹²³⁴⁵,Ding Sai¹²³⁴⁵,Zhang Wenjing¹²³⁴,Ma Xiaoyu⁵²³⁴,Niu Haoyi⁵²³⁴,Yuan Yuan¹²³⁴⁵^ORCID,Liu Changsheng¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory for Ultrafine Materials of Ministry of Education

2. East China University of Science and Technology

3. Shanghai 200237

4. PR China

5. Engineering Research Center for Biomedical Materials of Ministry of Education

Abstract

rhBMP-2 was tethered on surface of calcium phosphate cement via alendronate–heparin. This novel delivery system can concurrently satisfy high bioactive immobilization and sustainable release of rhBMP-2, and consequently induce rapid bone regeneration.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA01908D

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