Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I-Reference-Cited by-同舟云学术

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Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I

Published:2014 Issue:3 Volume:5 Page:352-357
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Zhou Yiqing¹²³⁴⁵,Guo Tianlin¹²³⁴⁵,Li Xitao¹²³⁴⁵,Dong Yi¹²³⁴⁵,Galatsis Paul⁶⁷⁸⁹,Johnson Douglas S.⁶⁷⁸⁹,Pan Zhengying¹²³⁴⁵

Affiliation:

1. Key laboratory of Chemical Genomics

2. School of Chemical Biology and Biotechnology

3. Peking University

4. Xili University Town

5. Shenzhen

6. Neuroscience Medicinal Chemistry and Chemical Biology

7. Pfizer Worldwide Research and Development

8. Cambridge

9. USA

Abstract

L1-Bpyne was discovered as a potent inhibitor and cell permeable probe of glyoxalase I.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00286A

Reference32 articles.

1. The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

2. Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy

3. Catalytic Mechanism of Glyoxalase I: A Theoretical Study

4. Glyoxalase inhibitors. A possible approach to anticancer agents

5. Glyoxalase I inhibitors in cancer chemotherapy

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2. Recent advances in the discovery and development of glyoxalase I inhibitors;Bioorganic & Medicinal Chemistry;2020-02

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4. DFT Investigations (Geometry Optimization, UV/Vis, FT-IR, NMR, HOMO-LUMO, FMO, MEP, NBO, Excited States) and the Syntheses of New Pyrimidine Dyes;CHINESE J STRUC CHEM;2018

5. Chemoproteomics Reveals the Antiproliferative Potential of Parkinson’s Disease Kinase Inhibitor LRRK2-IN-1 by Targeting PCNA Protein;Molecular Pharmaceutics;2018-07-11

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