Alkylsulfenyl thiocarbonates: precursors to hydropersulfides potently attenuate oxidative stress-Reference-Cited by-同舟云学术

Alkylsulfenyl thiocarbonates: precursors to hydropersulfides potently attenuate oxidative stress

Published:2021 Issue:23 Volume:12 Page:8252-8259
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Khodade Vinayak S.¹²³⁴,Aggarwal Sahil C.¹²³⁴,Pharoah Blaze M.¹²³⁴,Paolocci Nazareno⁵⁶³⁴⁷,Toscano John P.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Johns Hopkins University

3. Baltimore

4. USA

5. Division of Cardiology

6. Johns Hopkins University School of Medicine

7. Department of Biomedical Sciences

Abstract

A series of novel alkylsulfenyl thiocarbonates have been developed that efficiently release hydropersulfides (RSSH) over a range of half-lives. RSSH generation by these precursors potently ameliorates oxidative stress in H9c2 cardiac myoblasts.

Funder

National Institute of General Medical Sciences

National Heart, Lung, and Blood Institute

Division of Chemistry

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01550H

Reference46 articles.

1. Hydrogen Sulfide (H2S)-Releasing Compounds: Therapeutic Potential in Cardiovascular Diseases

2. Hydrogen Sulfide and Polysulfides as Biological Mediators

3. Discoveries of Hydrogen Sulfide as a Novel Cardiovascular Therapeutic

4. Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology

5. Chemical Biology of H2S Signaling through Persulfidation

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