Gold nanourchins and celastrol reorganize the nucleo- and cytoskeleton of glioblastoma cells-Reference-Cited by-同舟云学术

Gold nanourchins and celastrol reorganize the nucleo- and cytoskeleton of glioblastoma cells

Published:2018 Issue:4 Volume:10 Page:1716-1726
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Maysinger Dusica¹²³⁴,Moquin Alexandre¹²³⁴,Choi Jason¹²³⁴^ORCID,Kodiha Mohamed⁵²³⁴^ORCID,Stochaj Ursula⁵²³⁴^ORCID

Affiliation:

1. Department of Pharmacology and Therapeutics

2. McGill University

3. Montreal

4. Canada

5. Department of Physiology

Abstract

Gold nanourchins (AuNUs) associate with lysosomes and lipid droplets (LDs) in glioblastoma cells. AuNUs reorganize F-actin, microtubules and the nuclear lamina. This alters cell signaling and increases cell death. Cell injury is further enhanced by celastrol.

Funder

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NR/C7NR07833A

Reference72 articles.

1. Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology

2. Off to the Organelles - Killing Cancer Cells with Targeted Gold Nanoparticles