(−)-Epigallocatechin-3-gallate (EGCG) inhibits fibrillation, disaggregates amyloid fibrils of α-synuclein, and protects PC12 cells against α-synuclein-induced toxicity-Reference-Cited by-同舟云学术

(−)-Epigallocatechin-3-gallate (EGCG) inhibits fibrillation, disaggregates amyloid fibrils of α-synuclein, and protects PC12 cells against α-synuclein-induced toxicity

Published:2017 Issue:52 Volume:7 Page:32508-32517
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Zhao Juan¹²³⁴⁵,Liang Qingnan⁶⁷³⁸⁵,Sun Qing¹²³⁴⁵,Chen Congheng¹²³⁴⁵,Xu Lihui¹²³⁴⁵,Ding Yu⁶⁷³⁸⁵,Zhou Ping¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Molecular Engineering of Polymers

2. Department of Macromolecular Science

3. Fudan University

4. Shanghai 200433

5. China

6. Department of Physiology and Biophysics

7. School of Life Sciences

8. Shanghai 200438

Abstract

EGCG protects transduced PC12 cells against α-Syn-induced cytotoxicity by inhibiting the overexpression and fibrillation of α-Syn in the cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA03752J

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