Adipocyte-targeted celastrol delivery <i>via</i> biguanide-modified micelles improves treatment of obesity in DIO mice-Reference-Cited by-同舟云学术

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Adipocyte-targeted celastrol delivery via biguanide-modified micelles improves treatment of obesity in DIO mice

Published:2024 Issue:32 Volume:12 Page:7905-7914
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Ouyang Hongling¹,Zhang Yunxiao¹,Zhu Yueting¹,Gong Tao¹^ORCID,Zhang Zhirong¹,Fu Yao¹^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Abstract

Following intravenous administration, MET-CS-PBE@CLT micelles actively distribute to the adipose tissue via CD44-mediated targeting. The presence of biguanide groups ensure adipocyte targeting via plasma membrane monoamine transporters.

Funder

Fundamental Research Funds for the Central Universities

Higher Education Discipline Innovation Project

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB00777H

Reference52 articles.

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2. Obesity and aging: Molecular mechanisms and therapeutic approaches

3. S.Simati , A.Kokkinos , M.Dalamaga and G.Argyrakopoulou , Curr Obes Rep , 2023 , vol. 12, pp. 75–85

4. Pharmacogenomics of Medication‐Induced Weight Gain and Antiobesity Medications

5. An update on pharmacotherapeutic strategies for obesity

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