Capsaicin alleviates acute alcohol-induced pyroptosis by activating ESCRT-III-dependent cell membrane repair in hepatocytes-Reference-Cited by-同舟云学术

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Capsaicin alleviates acute alcohol-induced pyroptosis by activating ESCRT-III-dependent cell membrane repair in hepatocytes

Published:2024 Issue:16 Volume:15 Page:8395-8407
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Liu Meitong¹,Guo Jiakang¹,Lu Jing¹,Chen Yuelin¹,Deng Xuming²,Zhang Shengzhuo¹,Guan Shuang¹²^ORCID

Affiliation:

1. College of Food Science and Engineering, Jilin University, Changchun, Jilin 130012, China

2. State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China

Abstract

CAP alleviated acute alcohol-induced pyroptosis via TRPV1-Ca2+ influx-ESCRT-III-dependent membrane repair machinery, which relieved AALI.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO00806E

Reference46 articles.

1. Alcohol Metabolism

2. Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis

3. Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice

4. Kupffer cell pyroptosis mediated by METTL3 contributes to the progression of alcoholic steatohepatitis

5. Pro-inflammatory programmed cell death

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