Tight-binding inhibition of jack bean α-mannosidase by glycoimidazole clusters
Author:
Affiliation:
1. Laboratoire d'Innovation Moléculaire et Applications (LIMA)
2. Univ. de Strasbourg |Univ. de Haute-Alsace| CNRS (UMR 7042)
3. Equipe de Synthèse Organique et Molécules Bioactives (SYBIO)
4. ECPM
5. 67000 Strasbourg
Abstract
Examples of multimeric inhibitors displaying tight binding inhibition of a carbohydrate-processing enzyme are presented.
Funder
Centre National de la Recherche Scientifique
Université de Strasbourg
Centre International de Recherche aux Frontières de la Chimie
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00826H
Reference59 articles.
1. The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience
2. Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept
3. Emerging trends in enzyme inhibition by multivalent nanoconstructs
4. Are enzymes sensitive to the multivalent effect? Emerging evidence with glycosidases
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