Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy

Author:

Dong Huiling1,Gao Yanan1,Huang Xuefei2,Wu Xuanjun13ORCID

Affiliation:

1. National Glycoengineering Research Center, and Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine, Shandong University, Qingdao, Shandong 266237, China

2. Departments of Chemistry and Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, USA

3. Suzhou Research Institute, Shandong University, Suzhou, Jiangsu 215123, China

Abstract

The next generation of cancer theranostics based on Sia–ICG produced by the conjugation of sialic acid with indocyanine green (ICG) has been developed. Administration of Sia–ICG plus laser irradiation resulted in excellent ablation of solid tumors.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Natural Science Foundation of Jiangsu Province

Shandong University

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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