An analysis of the physicochemical properties of oral drugs from 2000 to 2022-Reference-Cited by-同舟云学术

An analysis of the physicochemical properties of oral drugs from 2000 to 2022

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Pirie Rachael¹^ORCID,Stanway-Gordon Harriet A.²^ORCID,Stewart Hannah L.²^ORCID,Wilson Kirsty L.²,Patton Summer¹,Tyerman Jack¹,Cole Daniel J.¹^ORCID,Fowler Katherine³^ORCID,Waring Michael J.²^ORCID

Affiliation:

1. Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU, UK

2. Cancer Research Horizons Newcastle Drug Discovery Unit, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne, NE1 7RU, UK

3. Cancer Research Horizons Therapeutic Innovation, Jonas Webb Building, Babraham Research Campus, Cambridge, CB22 3AT, UK

Abstract

Calculable physicochemical descriptors are a useful guide to assist compound design in medicinal chemistry.

Funder

Cancer Research UK

Engineering and Physical Sciences Research Council

Alan Turing Institute

Astex Pharmaceuticals

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00160E

Reference33 articles.

1. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

2. Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

3. The influence of drug-like concepts on decision-making in medicinal chemistry

4. Lipophilicity in drug discovery

5. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates