Silver complexes with substituted terpyridines as promising anticancer metallodrugs and their crystal structure, photoluminescence, and DNA interactions

Author:

Li Jiahe1234ORCID,Wang Zhiyuan1,Chen Zhongting4,Xue Xingyong1,Lin Kejuan1ORCID,Chen Hailan5ORCID,Pan Lixia2,Yuan Yulin6,Ma Zhen13ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People's Republic of China

2. National Engineering Research Center for Non-Food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, People's Republic of China

3. Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal

4. Department of Emergency Medicine, Second Affiliated Hospital of Zhejiang University, Key Laboratory of The Diagnosis and Treatment of Severe Trauma and Burns of Zhejiang Province, Clinical Research Center for Emergency and Critical Care Medicine of Zhejiang Province, Hangzhou 310009, People's Republic of China

5. School of Animal Science and Technology, Guangxi University, Nanning 530004, People's Republic of China

6. Department of Laboratory Medicine, Guangxi Academy of Medical Sciences, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, People's Republic of China

Abstract

Six silver hexafluoroantimonate complexes with 4′-(4′-substituted-phenyl)-terpyridine ligands show promising photoluminescence properties, DNA interactions and anticancer activities against carcinoma cell lines.

Funder

Fundação para a Ciência e a Tecnologia

National Natural Science Foundation of China

Guangxi Zhuang Region Health Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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