From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor-Reference-Cited by-同舟云学术

From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor

Published:2016 Issue:18 Volume:18 Page:4947-4953
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Borukhova Svetlana¹²³⁴,Noël Timothy¹²³⁴⁵,Metten Bert⁶⁷⁸,de Vos Eric⁶⁷⁸,Hessel Volker¹²³⁴

Affiliation:

1. Department of Chemical Engineering and Chemistry

2. Technische Universiteit Eindhoven

3. Den Dolech 2

4. Netherlands

5. Department of Organic Chemistry

6. Ajinomoto OmniChem N.V.

7. Cooppallaan 91

8. Belgium

Abstract

Bringing the strongest suits of flow chemistry together to deliver the greenest possible process for continuous manufacturing of a rufinamide precursor.

Funder

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/GC/C6GC01133K

Reference30 articles.

1. Bioassembly lines: a general mechanism for maintaining the specific architecture of a cell, with an implication for the function of a small RNA

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3. Continuous flow multi-step organic synthesis

4. Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes

5. Novel Process Windows - Gate to Maximizing Process Intensification via Flow Chemistry

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