Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones-Reference-Cited by-同舟云学术

Quadruplex DNA-guided ligand selection from dynamic combinatorial libraries of acylhydrazones

Published:2021 Issue:2 Volume:19 Page:379-386
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Reznichenko Oksana¹²³⁴⁵^ORCID,Cucchiarini Anne¹²³⁴⁵,Gabelica Valérie⁶⁷⁸⁹¹⁰^ORCID,Granzhan Anton¹²³⁴⁵^ORCID

Affiliation:

1. CNRS UMR9187

2. Inserm U1196

3. Institut Curie

4. PSL Research University

5. 91405 Orsay

6. Univ. Bordeaux

7. CNRS

8. INSERM

9. ARNA

10. UMR 5320

Abstract

Synthesis of dynamic combinatorial libraries of acylhydrazones in the presence of a G-quadruplex DNA template, followed by pull-down with streptavidin-coated magnetic beads, allows the identification of putative G-quadruplex binders.

Funder

Agence Nationale de la Recherche

Ministère de l'Enseignement Supérieur et de la Recherche

Institut Curie

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB01908A

Reference48 articles.

1. The Structure and Function of DNA G-Quadruplexes

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4. Quadruplex nucleic acids as targets for anticancer therapeutics

5. Quadruplex Nucleic Acids as Novel Therapeutic Targets

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