Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity-Reference-Cited by-同舟云学术

Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity

Published:2021 Issue:48 Volume:11 Page:30020-30029
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bizzarri Bruno Mattia¹^ORCID,Fanelli Angelica¹,Botta Lorenzo¹,De Angelis Marta²,Palamara Anna Teresa²³,Nencioni Lucia²,Saladino Raffaele¹^ORCID

Affiliation:

1. Ecological and Biological Sciences Department (DEB), University of Tuscia, Via S. Camillo de Lellis snc, 01100, Viterbo, Italy

2. Department of Public Health and Infectious Diseases, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy

3. Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy

Abstract

Amino imidazole carbonitrile derivatives decorated with α-amino acid side-chains have been synthesized by a multicomponent microwave assisted reaction inspired by the prebiotic chemistry of aminomalononitrile for generating high chemical diversity.

Funder

Agenzia Spaziale Italiana

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA05240C

Reference45 articles.

1. Multicomponent reactions: advanced tools for sustainable organic synthesis

2. Framing major prebiotic transitions as stages of protocell development: three challenges for origins-of-life research