New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C–H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3-Reference-Cited by-同舟云学术

New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C–H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3

Published:2016 Issue:48 Volume:14 Page:11402-11414
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ausekle Elina¹²³⁴,Ejaz Syeda Abida⁵⁶⁷⁸,Khan Shafi Ullah⁵⁶⁷⁸,Ehlers Peter¹²³⁴⁹,Villinger Alexander¹²³⁴,Lecka Joanna¹⁰¹¹¹²¹³¹⁴,Sévigny Jean¹⁰¹¹¹²¹³¹⁴,Iqbal Jamshed⁵⁶⁷⁸,Langer Peter¹²³⁴⁹

Affiliation:

1. Institut für Chemie

2. Universität Rostock

3. 18059 Rostock

4. Germany

5. Centre for Advanced Drug Research

6. COMSATS Institute of Information Technology

7. Abbottabad

8. Pakistan

9. Leibniz Institut für Katalyse an der Universität Rostock e.V.

10. Département de microbiologie-infectiologie et d'immunologie

11. Faculté de Médecine

12. Université Laval

13. Québec

14. Canada

Abstract

An efficient synthesis procedure for N-fused isoquinolines from gem-difluoroalkenes is described, and biological evaluation of the sythesized products as inhibitors of h-NPP-1 and -3 is reported.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB02236G

Reference73 articles.

1. Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

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4. Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS

5. Cyclopentadiene-Phosphine/Palladium-Catalyzed Synthesis of Indolizines from Pyrrole and 1,4-Dibromo-1,3-butadienes

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