Luminol anchors improve the electrochemical-tyrosine-click labelling of proteins-Reference-Cited by-同舟云学术

Luminol anchors improve the electrochemical-tyrosine-click labelling of proteins

Published:2021 Issue:46 Volume:12 Page:15374-15381
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Depienne Sébastien¹,Alvarez-Dorta Dimitri¹,Croyal Mikael²³⁴,Temgoua Ranil C. T.¹^ORCID,Charlier Cathy⁵,Deniaud David¹^ORCID,Mével Mathieu¹⁶^ORCID,Boujtita Mohammed¹,Gouin Sébastien G.¹^ORCID

Affiliation:

1. Université de Nantes, CNRS, CEISAM UMR 6230, F-44000 Nantes, France

2. Université de Nantes, CNRS, INSERM, L'institut du Thorax, F-44000 Nantes, France

3. Université de Nantes, CHU Nantes, Inserm, CNRS, SFR Santé, Inserm UMS 016, CNRS UMS 3556, F-44000 Nantes, France

4. CRNH-Ouest Mass Spectrometry Core Facility, F-44000 Nantes, France

5. IMPACT Platform, Interactions Moléculaires Puces ACTivités, UMR CNRS 6286 UFIP, Université de Nantes, F-44000 Nantes, France

6. INSERM UMR 1089, Université de Nantes, CHU de Nantes, 44200 Nantes, France

Abstract

We assessed the relative efficiencies of tyrosine anchors in the electrochemical conjugation of peptides and proteins. Luminol derivatives showed faster reaction kinetics, complete tyrosine-chemoselectivity, and possible double modification.

Funder

Centre National de la Recherche Scientifique

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC04809K

Reference52 articles.

1. Advances in Chemical Protein Modification

2. Selective chemical protein modification