Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations-Reference-Cited by-同舟云学术

Pyrrovobasine, hybrid alkylated pyrraline monoterpene indole alkaloid pseudodimer discovered using a combination of mass spectral and NMR-based machine learning annotations

Published:2022 Issue:1 Volume:20 Page:98-105
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fouotsa Hugues¹²³^ORCID,Mkounga Pierre³,Lannang Alain Meli⁴,Vanheuverzwijn Jérôme²,Zhou Zhiyu²,Leblanc Karine¹,Rharrabti Somia¹,Nkengfack Augustin Ephrem³,Gallard Jean-François⁵,Fontaine Véronique²,Meyer Franck²,Poupon Erwan¹^ORCID,Le Pogam Pierre¹^ORCID,Beniddir Mehdi A.¹^ORCID

Affiliation:

1. Équipe “Chimie des Substances Naturelles” Université Paris-Saclay, CNRS, BioCIS, 5 rue J.-B. Clément, 92290 Châtenay-Malabry, France

2. Faculty of Pharmacy, Microbiology, Bioorganic and Macromolecular Chemistry Unit, Université Libre de Bruxelles, Campus de la Plaine-CP 206/04, Boulevard du Triomphe, ACC.2, Po Box 1050, Belgium

3. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon

4. Department of Chemistry, Higher Teachers Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon

5. Institut de Chimie des Substances Naturelles, CNRS, ICSN UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France

Abstract

The MS2-guided phytochemical investigation of Voacanga africana stem bark resulted in the isolation of pyrrovobasine, the first pyrraline-containing MIA.

Funder

Organisation for the Prohibition of Chemical Weapons

Académie de recherche et d'enseignement supérieur

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D1OB01791H

Reference50 articles.

1. Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity