Synthesis of controlled-size silver nanoparticles for the administration of methotrexate drug and its activity in colon and lung cancer cells

Author:

Rozalen M.12345ORCID,Sánchez-Polo M.12345,Fernández-Perales M.12345,Widmann T. J.678910,Rivera-Utrilla J.12345

Affiliation:

1. Department of Inorganic Chemistry

2. Faculty of Science

3. University of Granada

4. 18071 Granada

5. Spain

6. Department of Genomic Medicine

7. GENYO

8. Centre for Genomics & Oncology (Pfizer - University of Granada & Andalusian Regional Government)

9. PTS Granada

10. Granada 18016

Abstract

A controlled synthesis of methotrexate (MTX) silver nanoparticles (AgNPs-MTX) using borohydride and citrate as reduction and reduction/capping agents, respectively, was performed in order to obtain AgNPs-MTX conjugates with a narrow size distribution.

Funder

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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