A novel nano delivery system targeting different stages of osteoclasts

Author:

Zhang Bongsong1ORCID,Zhao Juzhi1,Yan Hongji234ORCID,Zhao Yufang15,Tian Hui1,Wang Cao1,Wang Ruiqi1,Jin Jiaming1,Chen Yue1,Yang Chaofan1,LI Chunfeng1,Jiao Yanwen1,Zheng Kaipeng1,Zhu Fuxing1,Tian Weiming1ORCID

Affiliation:

1. School of Life Science and Technology, Harbin Institute of Technology, 150080 Harbin, China

2. Division of Glycoscience, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH, Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden

3. AIMES—Center for the Advancement of Integrated Medical and Engineering Sciences at Karolinska Institutet and KTH Royal Institute of Technology, Stockholm, Sweden

4. Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden

5. Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, 150080 Harbin, China

Abstract

Novel delivery systems of two dual-targeting nanoparticles based on HA, CGRPR-anti, and TRAP peptides were constructed to achieve targeting of osteoclasts at different stages of maturation for delivery relevant drugs.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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